Mitogen-activated protein kinase 11 (MAPK11)

About Mitogen-activated protein kinase 11

Mitogen-activated protein kinase 11 (MAPK11) is a protein from Homo sapiens identified by UniProt accession Q15759, 364 residues long. MolForge cross-references it against 0 known binders and 158 disease associations.

Target properties

Protein name	Mitogen-activated protein kinase 11
UniProt accession	Q15759
Gene	MAPK11
Organism	Homo sapiens
Length	364 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (7)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (158)

Diseases linked to this target (Open Targets).

metastatic colorectal cancer · score 0.54
colorectal cancer · score 0.51
colorectal neoplasm · score 0.50
neoplasm · score 0.42
hepatocellular carcinoma · score 0.38
esophageal cancer · score 0.37
gastrointestinal stromal tumor · score 0.35
Facioscapulohumeral dystrophy · score 0.29
acute coronary syndrome · score 0.28
malignant colon neoplasm · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15759-F1	alphafold	PREDICTED	89.67	—

Amino-acid sequence (364 residues)

MSGPRAGFYR QELNKTVWEV PQRLQGLRPV GSGAYGSVCS AYDARLRQKV AVKKLSRPFQ SLIHARRTYR ELRLLKHLKH ENVIGLLDVF TPATSIEDFS EVYLVTTLMG ADLNNIVKCQ ALSDEHVQFL VYQLLRGLKY IHSAGIIHRD LKPSNVAVNE DCELRILDFG LARQADEEMT GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLQGK ALFPGSDYID QLKRIMEVVG TPSPEVLAKI SSEHARTYIQ SLPPMPQKDL SSIFRGANPL AIDLLGRMLV LDSDQRVSAA EALAHAYFSQ YHDPEDEPEA EPYDESVEAK ERTLEEWKEL TYQEVLSFKP PEPPKPPGSL EIEQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards