Ephrin-B3 (EFNB3)

About Ephrin-B3

Ephrin-B3 (EFNB3) is a protein from Homo sapiens identified by UniProt accession Q15768, 340 residues long. MolForge cross-references it against 0 known binders and 150 disease associations.

Target properties

Protein name	Ephrin-B3
UniProt accession	Q15768
Gene	EFNB3
Organism	Homo sapiens
Length	340 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (150)

Diseases linked to this target (Open Targets).

alcohol consumption measurement · score 0.10
Benign familial chorea · score 0.10
non-small cell lung carcinoma · score 0.09
Ataxia - oculomotor apraxia type 1 · score 0.08
spinocerebellar ataxia type 23 · score 0.07
Spinocerebellar ataxia type 40 · score 0.07
Dysequilibrium syndrome · score 0.07
Rare hereditary ataxia · score 0.07
spinocerebellar ataxia type 35 · score 0.06
episodic ataxia type 5 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15768-F1	alphafold	PREDICTED	67.79	—

Amino-acid sequence (340 residues)

MGPPHSGPGG VRVGALLLLG VLGLVSGLSL EPVYWNSANK RFQAEGGYVL YPQIGDRLDL LCPRARPPGP HSSPNYEFYK LYLVGGAQGR RCEAPPAPNL LLTCDRPDLD LRFTIKFQEY SPNLWGHEFR SHHDYYIIAT SDGTREGLES LQGGVCLTRG MKVLLRVGQS PRGGAVPRKP VSEMPMERDR GAAHSLEPGK ENLPGDPTSN ATSRGAEGPL PPPSMPAVAG AAGGLALLLL GVAGAGGAMC WRRRRAKPSE SRHPGPGSFG RGGSLGLGGG GGMGPREAEP GELGIALRGG GAADPPFCPH YEKVSGDYGH PVYIVQDGPP QSPPNIYYKV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards