About Zinc finger protein with KRAB and SCAN domains 8
Zinc finger protein with KRAB and SCAN domains 8 (ZKSCAN8) is a protein
from Homo sapiens identified by UniProt accession
Q15776, 578 residues long.
MolForge cross-references it against 0 known binders and
49 disease associations.
Target properties
| Protein name | Zinc finger protein with KRAB and SCAN domains 8 |
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| UniProt accession | Q15776 |
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| Gene | ZKSCAN8 |
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| Organism | Homo sapiens |
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| Length | 578 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (49)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- type 1 diabetes mellitus · score 0.32
- forced expiratory volume · score 0.23
- wellbeing measurement · score 0.15
- psoriasis vulgaris · score 0.14
- unipolar depression · score 0.14
- psoriatic arthritis · score 0.11
- mathematical ability · score 0.10
- lean body mass · score 0.09
- psoriasis · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15776-F1 | alphafold | PREDICTED | 64.85 | — |
Amino-acid sequence (578 residues)
MAEESRKPSA PSPPDQTPEE DLVIVKVEED HGWDQESSLH ESNPLGQEVF RLRFRQLRYQ ETLGPREALI QLRALCHQWL RPDLNTKEQI LELLVLEQFL TILPEELQTL VKEHQLENGE EVVTLLEDLE RQIDILGRPV SARVHGHRVL WEEVVHSASA PEPPNTQLQS EATQHKSPVP QESQERAMST SQSPTRSQKG SSGDQEMTAT LLTAGFQTLE KIEDMAVSLI REEWLLDPSQ KDLCRDNRPE NFRNMFSLGG ETRSENRELA SKQVISTGIQ PHGETAAKCN GDVIRGLEHE EARDLLGRLE RQRGNPTQER RHKCDECGKS FAQSSGLVRH WRIHTGEKPY QCNVCGKAFS YRSALLSHQD IHNKVKRYHC KECGKAFSQN TGLILHQRIH TGEKPYQCNQ CGKAFSQSAG LILHQRIHSG ERPYECNECG KAFSHSSHLI GHQRIHTGEK PYECDECGKT FRRSSHLIGH QRSHTGEKPY KCNECGRAFS QKSGLIEHQR IHTGERPYKC KECGKAFNGN TGLIQHLRIH TGEKPYQCNE CGKAFIQRSS LIRHQRIHSG EKSESISV
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