About Metallophosphoesterase MPPED2
Metallophosphoesterase MPPED2 (MPPED2) is a protein
from Homo sapiens identified by UniProt accession
Q15777, 294 residues long.
MolForge cross-references it against 0 known binders and
147 disease associations.
Target properties
| Protein name | Metallophosphoesterase MPPED2 |
|---|
| UniProt accession | Q15777 |
|---|
| Gene | MPPED2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 294 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (147)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.48
- body height · score 0.46
- risk-taking behaviour · score 0.45
- migraine disorder · score 0.44
- pulse pressure measurement · score 0.43
- cortical thickness · score 0.42
- lean body mass · score 0.42
- body mass index · score 0.38
- fat body mass · score 0.37
- glomerular filtration rate · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15777-F1 | alphafold | PREDICTED | 95.18 | — |
Amino-acid sequence (294 residues)
MAHGIPSQGK VTITVDEYSS NPTQAFTHYN INQSRFQPPH VHMVDPIPYD TPKPAGHTRF VCISDTHSRT DGIQMPYGDI LLHTGDFTEL GLPSEVKKFN DWLGNLPYEY KIVIAGNHEL TFDKEFMADL VKQDYYRFPS VSKLKPEDFD NVQSLLTNSI YLQDSEVTVK GFRIYGAPWT PWFNGWGFNL PRGQSLLDKW NLIPEGIDIL MTHGPPLGFR DWVPKELQRV GCVELLNTVQ RRVRPKLHVF GGIHEGYGIM TDGYTTYINA STCTVSFQPT NPPIIFDLPN PQGS
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