Chitinase-3-like protein 2 (CHI3L2)

About Chitinase-3-like protein 2

Chitinase-3-like protein 2 (CHI3L2) is a protein from Homo sapiens identified by UniProt accession Q15782, 390 residues long. MolForge cross-references it against 0 known binders and 112 disease associations.

Target properties

Protein name	Chitinase-3-like protein 2
UniProt accession	Q15782
Gene	CHI3L2
Organism	Homo sapiens
Length	390 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (112)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.38
blood protein measurement · score 0.36
leukocyte count · score 0.22
myeloid white cell count · score 0.20
FEV/FVC ratio · score 0.18
forced expiratory volume · score 0.17
platelet count · score 0.16
platelet crit · score 0.12
reticulocyte count · score 0.11
neutrophil count · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15782-F1	alphafold	PREDICTED	94.62	—

Amino-acid sequence (390 residues)

MGATTMDQKS LWAGVVVLLL LQGGSAYKLV CYFTNWSQDR QEPGKFTPEN IDPFLCSHLI YSFASIENNK VIIKDKSEVM LYQTINSLKT KNPKLKILLS IGGYLFGSKG FHPMVDSSTS RLEFINSIIL FLRNHNFDGL DVSWIYPDQK ENTHFTVLIH ELAEAFQKDF TKSTKERLLL TAGVSAGRQM IDNSYQVEKL AKDLDFINLL SFDFHGSWEK PLITGHNSPL SKGWQDRGPS SYYNVEYAVG YWIHKGMPSE KVVMGIPTYG HSFTLASAET TVGAPASGPG AAGPITESSG FLAYYEICQF LKGAKITRLQ DQQVPYAVKG NQWVGYDDVK SMETKVQFLK NLNLGGAMIW SIDMDDFTGK SCNQGPYPLV QAVKRSLGSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards