Neurogenic differentiation factor 2 (NEUROD2)

About Neurogenic differentiation factor 2

Neurogenic differentiation factor 2 (NEUROD2) is a protein from Homo sapiens identified by UniProt accession Q15784, 382 residues long. MolForge cross-references it against 0 known binders and 218 disease associations.

Target properties

Protein name	Neurogenic differentiation factor 2
UniProt accession	Q15784
Gene	NEUROD2
Organism	Homo sapiens
Length	382 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (218)

Diseases linked to this target (Open Targets).

developmental and epileptic encephalopathy · score 0.58
neurodegenerative disease · score 0.32
erythrocyte count · score 0.26
red blood cell density measurement · score 0.22
genetic disorder · score 0.19
self reported educational attainment · score 0.12
refractive error · score 0.10
hematocrit · score 0.08
mathematical ability · score 0.07
Adult-onset autosomal recessive cerebellar ataxia · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15784-F1	alphafold	PREDICTED	60.07	—

Amino-acid sequence (382 residues)

MLTRLFSEPG LLSDVPKFAS WGDGEDDEPR SDKGDAPPPP PPAPGPGAPG PARAAKPVPL RGEEGTEATL AEVKEEGELG GEEEEEEEEE EGLDEAEGER PKKRGPKKRK MTKARLERSK LRRQKANARE RNRMHDLNAA LDNLRKVVPC YSKTQKLSKI ETLRLAKNYI WALSEILRSG KRPDLVSYVQ TLCKGLSQPT TNLVAGCLQL NSRNFLTEQG ADGAGRFHGS GGPFAMHPYP YPCSRLAGAQ CQAAGGLGGG AAHALRTHGY CAAYETLYAA AGGGGASPDY NSSEYEGPLS PPLCLNGNFS LKQDSSPDHE KSYHYSMHYS ALPGSRPTGH GLVFGSSAVR GGVHSENLLS YDMHLHHDRG PMYEELNAFF HN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards