About Tubulin-specific chaperone E
Tubulin-specific chaperone E (TBCE) is a protein
from Homo sapiens identified by UniProt accession
Q15813, 527 residues long.
MolForge cross-references it against 0 known binders and
472 disease associations.
Target properties
| Protein name | Tubulin-specific chaperone E |
|---|
| UniProt accession | Q15813 |
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| Gene | TBCE |
|---|
| Organism | Homo sapiens |
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| Length | 527 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (472)
Diseases linked to this target (Open Targets).
- hypoparathyroidism-retardation-dysmorphism syndrome · score 0.76
- autosomal recessive Kenny-Caffey syndrome · score 0.72
- encephalopathy, progressive, with amyotrophy and optic atrophy · score 0.64
- neurodegenerative disease · score 0.53
- genetic disorder · score 0.47
- Sanjad-Sakati syndrome · score 0.46
- Kenny-Caffey syndrome · score 0.46
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 11 · score 0.34
- mathematical ability · score 0.31
- self reported educational attainment · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15813-F1 | alphafold | PREDICTED | 89.18 | — |
Amino-acid sequence (527 residues)
MSDTLTADVI GRRVEVNGEH ATVRFAGVVP PVAGPWLGVE WDNPERGKHD GSHEGTVYFK CRHPTGGSFI RPNKVNFGTD FLTAIKNRYV LEDGPEEDRK EQIVTIGNKP VETIGFDSIM KQQSQLSKLQ EVSLRNCAVS CAGEKGGVAE ACPNIRKVDL SKNLLSSWDE VIHIADQLRH LEVLNVSENK LKFPSGSVLT GTLSVLKVLV LNQTGITWAE VLRCVAGCPG LEELYLESNN IFISERPTDV LQTVKLLDLS SNQLIDENQL YLIAHLPRLE QLILSDTGIS SLHFPDAGIG CKTSMFPSLK YLVVNDNQIS QWSFFNELEK LPSLRALSCL RNPLTKEDKE AETARLLIIA SIGQLKTLNK CEILPEERRR AELDYRKAFG NEWKQAGGHK DPEKNRLSEE FLTAHPRYQF LCLKYGAPED WELKTQQPLM LKNQLLTLKI KYPHQLDQKV LEKQLPGSMT IQKVKGLLSR LLKVPVSDLL LSYESPKKPG REIELENDLK SLQFYSVENG DCLLVRW
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