About Neuronal pentraxin-1
Neuronal pentraxin-1 (NPTX1) is a protein
from Homo sapiens identified by UniProt accession
Q15818, 432 residues long.
MolForge cross-references it against 0 known binders and
105 disease associations.
Target properties
| Protein name | Neuronal pentraxin-1 |
|---|
| UniProt accession | Q15818 |
|---|
| Gene | NPTX1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 432 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (105)
Diseases linked to this target (Open Targets).
- body mass index · score 0.34
- genetic disorder · score 0.34
- blood protein measurement · score 0.32
- thalamus volume · score 0.30
- Irritability · score 0.30
- body fat percentage · score 0.14
- hepatocellular carcinoma · score 0.08
- melanoma · score 0.08
- gonorrhea · score 0.08
- neoplasm · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15818-F1 | alphafold | PREDICTED | 75.77 | — |
Amino-acid sequence (432 residues)
MPAGRAARTC ALLALCLLGA GAQDFGPTRF ICTSVPVDAD MCAASVAAGG AEELRSSVLQ LRETVLQQKE TILSQKETIR ELTAKLGRCE SQSTLDPGAG EARAGGGRKQ PGSGKNTMGD LSRTPAAETL SQLGQTLQSL KTRLENLEQY SRLNSSSQTN SLKDLLQSKI DELERQVLSR VNTLEEGKGG PRNDTEERVK IETALTSLHQ RISELEKGQK DNRPGDKFQL TFPLRTNYMY AKVKKSLPEM YAFTVCMWLK SSATPGVGTP FSYAVPGQAN ELVLIEWGNN PMEILINDKV AKLPFVINDG KWHHICVTWT TRDGVWEAYQ DGTQGGSGEN LAPYHPIKPQ GVLVLGQEQD TLGGGFDATQ AFVGELAHFN IWDRKLTPGE VYNLATCSTK ALSGNVIAWA ESHIEIYGGA TKWTFEACRQ IN
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