Ubiquitin-conjugating enzyme E2 variant 2 (UBE2V2)

About Ubiquitin-conjugating enzyme E2 variant 2

Ubiquitin-conjugating enzyme E2 variant 2 (UBE2V2) is a protein from Homo sapiens identified by UniProt accession Q15819, 145 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.

Target properties

Protein name	Ubiquitin-conjugating enzyme E2 variant 2
UniProt accession	Q15819
Gene	UBE2V2
Organism	Homo sapiens
Length	145 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (59)

Diseases linked to this target (Open Targets).

lung adenocarcinoma · score 0.29
breast adenocarcinoma · score 0.28
mean corpuscular volume · score 0.25
squamous cell lung carcinoma · score 0.23
mean reticulocyte volume · score 0.23
lean body mass · score 0.19
intraocular pressure measurement · score 0.16
Red cell distribution width · score 0.14
age at menopause · score 0.12
hemoglobin measurement · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15819-F1	alphafold	PREDICTED	94.37	—

Amino-acid sequence (145 residues)

MAVSTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI IGPPRTNYEN RIYSLKVECG PKYPEAPPSV RFVTKINMNG INNSSGMVDA RSIPVLAKWQ NSYSIKVVLQ ELRRLMMSKE NMKLPQPPEG QTYNN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards