About Cystatin-M
Cystatin-M (CST6) is a protein
from Homo sapiens identified by UniProt accession
Q15828, 149 residues long.
MolForge cross-references it against 0 known binders and
156 disease associations.
Target properties
| Protein name | Cystatin-M |
|---|
| UniProt accession | Q15828 |
|---|
| Gene | CST6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 149 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (156)
Diseases linked to this target (Open Targets).
- autosomal recessive hypohidrotic ectodermal dysplasia · score 0.38
- body height · score 0.13
- cerebrospinal fluid biomarker measurement · score 0.13
- blood protein measurement · score 0.12
- neoplasm · score 0.10
- BMI-adjusted waist circumference · score 0.10
- Miyoshi myopathy · score 0.09
- cancer · score 0.08
- melanoma · score 0.08
- Keratoderma hereditarium mutilans with ichthyosis · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15828-F1 | alphafold | PREDICTED | 90.41 | — |
Amino-acid sequence (149 residues)
MARSNLPLAL GLALVAFCLL ALPRDARARP QERMVGELRD LSPDDPQVQK AAQAAVASYN MGSNSIYYFR DTHIIKAQSQ LVAGIKYFLT MEMGSTDCRK TRVTGDHVDL TTCPLAAGAQ QEKLRCDFEV LVVPWQNSSQ LLKHNCVQM
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