About Syntaxin-binding protein 2
Syntaxin-binding protein 2 (STXBP2) is a protein
from Homo sapiens identified by UniProt accession
Q15833, 593 residues long.
MolForge cross-references it against 0 known binders and
82 disease associations.
Target properties
| Protein name | Syntaxin-binding protein 2 |
|---|
| UniProt accession | Q15833 |
|---|
| Gene | STXBP2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 593 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (82)
Diseases linked to this target (Open Targets).
- Familial hemophagocytic lymphohistiocytosis · score 0.80
- autoinflammatory syndrome · score 0.47
- breast adenocarcinoma · score 0.25
- genetic disorder · score 0.19
- neuropathic pain · score 0.17
- Thrombocytopenia · score 0.15
- Abnormal bleeding · score 0.15
- glioblastoma multiforme · score 0.14
- Recurrent infection due to specific granule deficiency · score 0.04
- neutrophil immunodeficiency syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15833-F1 | alphafold | PREDICTED | 89.97 | — |
Amino-acid sequence (593 residues)
MAPSGLKAVV GEKILSGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI LAEGITIVED INKRREPIPS LEAIYLLSPT EKSVQALIKD FQGTPTFTYK AAHIFFTDTC PEPLFSELGR SRLAKVVKTL KEIHLAFLPY EAQVFSLDAP HSTYNLYCPF RAEERTRQLE VLAQQIATLC ATLQEYPAIR YRKGPEDTAQ LAHAVLAKLN AFKADTPSLG EGPEKTRSQL LIMDRAADPV SPLLHELTFQ AMAYDLLDIE QDTYRYETTG LSEAREKAVL LDEDDDLWVE LRHMHIADVS KKVTELLRTF CESKRLTTDK ANIKDLSQIL KKMPQYQKEL NKYSTHLHLA DDCMKHFKGS VEKLCSVEQD LAMGSDAEGE KIKDSMKLIV PVLLDAAVPA YDKIRVLLLY ILLRNGVSEE NLAKLIQHAN VQAHSSLIRN LEQLGGTVTN PGGSGTSSRL EPRERMEPTY QLSRWTPVIK DVMEDAVEDR LDRNLWPFVS DPAPTASSQA AVSARFGHWH KNKAGIEARA GPRLIVYVMG GVAMSEMRAA YEVTRATEGK WEVLIGSSHI LTPTRFLDDL KALDKKLEDI ALP
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