About Rhodopsin kinase GRK1
Rhodopsin kinase GRK1 (GRK1) is a protein
from Homo sapiens identified by UniProt accession
Q15835, 563 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Rhodopsin kinase GRK1 |
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| UniProt accession | Q15835 |
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| Gene | GRK1 |
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| Organism | Homo sapiens |
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| Length | 563 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (75)
Diseases linked to this target (Open Targets).
- Oguchi disease · score 0.69
- congenital stationary night blindness · score 0.26
- neuroinflammatory disorder · score 0.22
- genetic disorder · score 0.19
- ovarian cancer · score 0.18
- breast adenocarcinoma · score 0.11
- age-related macular degeneration · score 0.07
- X-linked retinal dysplasia · score 0.07
- retinitis pigmentosa · score 0.06
- Familial exudative vitreoretinopathy · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15835-F1 | alphafold | PREDICTED | 91.28 | — |
Amino-acid sequence (563 residues)
MDFGSLETVV ANSAFIAARG SFDGSSSQPS RDKKYLAKLK LPPLSKCESL RDSLSLEFES VCLEQPIGKK LFQQFLQSAE KHLPALELWK DIEDYDTADN DLQPQKAQTI LAQYLDPQAK LFCSFLDEGI VAKFKEGPVE IQDGLFQPLL QATLAHLGQA PFQEYLGSLY FLRFLQWKWL EAQPMGEDWF LDFRVLGKGG FGEVSACQMK ATGKLYACKK LNKKRLKKRK GYQGAMVEKK ILMKVHSRFI VSLAYAFETK ADLCLVMTIM NGGDIRYHIY NVNEENPGFP EPRALFYTAQ IICGLEHLHQ RRIVYRDLKP ENVLLDNDGN VRISDLGLAV ELLDGQSKTK GYAGTPGFMA PELLQGEEYD FSVDYFALGV TLYEMIAARG PFRARGEKVE NKELKHRIIS EPVKYPDKFS QASKDFCEAL LEKDPEKRLG FRDETCDKLR AHPLFKDLNW RQLEAGMLMP PFIPDSKTVY AKDIQDVGAF STVKGVAFDK TDTEFFQEFA TGNCPIPWQE EMIETGIFGE LNVWRSDGQM PDDMKGISGG SSSSSKSGMC LVS
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