Ubiquitin-like protein NEDD8 (NEDD8)

About Ubiquitin-like protein NEDD8

Ubiquitin-like protein NEDD8 (NEDD8) is a protein from Homo sapiens identified by UniProt accession Q15843, 81 residues long. MolForge cross-references it against 0 known binders and 128 disease associations.

Target properties

Protein name	Ubiquitin-like protein NEDD8
UniProt accession	Q15843
Gene	NEDD8
Organism	Homo sapiens
Length	81 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (128)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
platelet count · score 0.25
mean corpuscular volume · score 0.24
mean corpuscular hemoglobin · score 0.21
erythrocyte count · score 0.21
lung adenocarcinoma · score 0.19
breast adenocarcinoma · score 0.18
telomere length · score 0.16
uterine fibroid · score 0.16
smoking behaviour measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15843-F1	alphafold	PREDICTED	89.93	—

Amino-acid sequence (81 residues)

MLIKVKTLTG KEIEIDIEPT DKVERIKERV EEKEGIPPQQ QRLIYSGKQM NDEKTAADYK ILGGSVLHLV LALRGGGGLR Q

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards