Endosomal transmembrane epsin interactor 1 (ENTREP1)

About Endosomal transmembrane epsin interactor 1

Endosomal transmembrane epsin interactor 1 (ENTREP1) is a protein from Homo sapiens identified by UniProt accession Q15884, 450 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	Endosomal transmembrane epsin interactor 1
UniProt accession	Q15884
Gene	ENTREP1
Organism	Homo sapiens
Length	450 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

glucose measurement · score 0.24
intelligence · score 0.12
self reported educational attainment · score 0.12
Familial prostate cancer · score 0.11
prostate carcinoma · score 0.11
prostate cancer · score 0.11
schizophrenia · score 0.09
red blood cell density measurement · score 0.08
hemoglobin measurement · score 0.07
breast cancer · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15884-F1	alphafold	PREDICTED	60.58	—

Amino-acid sequence (450 residues)

MILLVNLFVL LSVVCVLLNL AGFILGCQGA QFVSSVPRCD LVDLGEGKIC FCCEEFQPAK CTDKENALKL FPVQPCSAVH LLLKKVLFAL CALNALTTTV CLVAAALRYL QIFATRRSCI DESQISAEEA EDHGRIPDPD DFVPPVPPPS YFATFYSCTP RMNRRMVGPD VIPLPHIYGA RIKGVEVFCP LDPPPPYEAV VSQMDQEQGS SFQMSEGSEA AVIPLDLGCT QVTQDGDIPN IPAEENASTS TPSSTLVRPI RSRRALPPLR TRSKSDPVLH PSEERAAPVL SCEAATQTER RLDLAAVTLR RGLRSRASRC RPRSLIDYKS YMDTKLLVAR FLEQSSCTMT PDIHELVENI KSVLKSDEEH MEEAITSASF LEQIMAPLQP STSRAHKLPS RRQPGLLHLQ SCGDLHTFTP AGRPRAERRP RRVEAERPHS LIGVIRETVL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards