V-type proton ATPase subunit S1 (ATP6AP1)

About V-type proton ATPase subunit S1

V-type proton ATPase subunit S1 (ATP6AP1) is a protein from Homo sapiens identified by UniProt accession Q15904, 470 residues long. MolForge cross-references it against 0 known binders and 109 disease associations.

Target properties

Protein name	V-type proton ATPase subunit S1
UniProt accession	Q15904
Gene	ATP6AP1
Organism	Homo sapiens
Length	470 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (109)

Diseases linked to this target (Open Targets).

immunodeficiency 47 · score 0.75
neurodegenerative disease · score 0.53
congenital disorder of glycosylation type II · score 0.37
breast adenocarcinoma · score 0.21
genetic disorder · score 0.17
glioblastoma multiforme · score 0.15
breast cancer · score 0.08
Granular Cell Tumor · score 0.07
reading · score 0.07
neoplasm · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15904-F1	alphafold	PREDICTED	78.80	—

Amino-acid sequence (470 residues)

MMAAMATARV RMGPRCAQAL WRMPWLPVFL SLAAAAAAAA AEQQVPLVLW SSDRDLWAPA ADTHEGHITS DLQLSTYLDP ALELGPRNVL LFLQDKLSIE DFTAYGGVFG NKQDSAFSNL ENALDLAPSS LVLPAVDWYA VSTLTTYLQE KLGASPLHVD LATLRELKLN ASLPALLLIR LPYTASSGLM APREVLTGND EVIGQVLSTL KSEDVPYTAA LTAVRPSRVA RDVAVVAGGL GRQLLQKQPV SPVIHPPVSY NDTAPRILFW AQNFSVAYKD QWEDLTPLTF GVQELNLTGS FWNDSFARLS LTYERLFGTT VTFKFILANR LYPVSARHWF TMERLEVHSN GSVAYFNASQ VTGPSIYSFH CEYVSSLSKK GSLLVARTQP SPWQMMLQDF QIQAFNVMGE QFSYASDCAS FFSPGIWMGL LTSLFMLFIF TYGLHMILSL KTMDRFDDHK GPTISLTQIV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards