About Vacuolar protein sorting-associated protein 72 homolog
Vacuolar protein sorting-associated protein 72 homolog (VPS72) is a protein
from Homo sapiens identified by UniProt accession
Q15906, 364 residues long.
MolForge cross-references it against 0 known binders and
17 disease associations.
Target properties
| Protein name | Vacuolar protein sorting-associated protein 72 homolog |
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| UniProt accession | Q15906 |
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| Gene | VPS72 |
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| Organism | Homo sapiens |
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| Length | 364 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (17)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- breast adenocarcinoma · score 0.22
- acute myeloid leukemia · score 0.12
- hepatocellular carcinoma · score 0.10
- melanoma · score 0.08
- neoplasm · score 0.04
- blood protein measurement · score 0.02
- cancer · score 0.02
- dysplastic nevus · score 0.01
- metastatic melanoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15906-F1 | alphafold | PREDICTED | 73.01 | — |
Amino-acid sequence (364 residues)
MSLAGGRAPR KTAGNRLSGL LEAEEEDEFY QTTYGGFTEE SGDDEYQGDQ SDTEDEVDSD FDIDEGDEPS SDGEAEEPRR KRRVVTKAYK EPLKSLRPRK VNTPAGSSQK AREEKALLPL ELQDDGSDSR KSMRQSTAEH TRQTFLRVQE RQGQSRRRKG PHCERPLTQE ELLREAKITE ELNLRSLETY ERLEADKKKQ VHKKRKCPGP IITYHSVTVP LVGEPGPKEE NVDIEGLDPA PSVSALTPHA GTGPVNPPAR CSRTFITFSD DATFEEWFPQ GRPPKVPVRE VCPVTHRPAL YRDPVTDIPY ATARAFKIIR EAYKKYITAH GLPPTASALG PGPPPPEPLP GSGPRALRQK IVIK
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