Zinc finger protein 77 (ZNF77)

About Zinc finger protein 77

Zinc finger protein 77 (ZNF77) is a protein from Homo sapiens identified by UniProt accession Q15935, 545 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.

Target properties

Protein name	Zinc finger protein 77
UniProt accession	Q15935
Gene	ZNF77
Organism	Homo sapiens
Length	545 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (92)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.24
neoplasm · score 0.07
chronic kidney disease · score 0.03
juvenile idiopathic arthritis · score 0.01
myocardial infarction · score 0.01
retinal degeneration · score 0.01
systemic juvenile idiopathic arthritis · score 0.01
acute kidney failure · score 0.01
cancer · score 0.01
infection · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15935-F1	alphafold	PREDICTED	68.24	—

Amino-acid sequence (545 residues)

MDCVIFEEVA VNFTPEEWAL LDHAQRSLYR DVMLETCRNL ASLDCYIYVR TSGSSSQRDV FGNGISNDEE IVKFTGSDSW SIFGENWRFD NTGDQHQIPQ RHLRSQLGRL CESNEGHQCG ETLSQTANLL VHKSYPTEAK PSECTKCGKA FENRQRSHTG QRPCKECGQA CSCLSCQSPP MKTQTVEKPC NCQDSRTASV TYVKSLSSKK SYECQKCGKA FICPSSFRGH VNSHHGQKTH ACKVCGKTFM YYSYLTRHVR THTGEKPYEC KECGKAFSCP SYFREHVRTH TGEKPYECKH CGKSFSCYSS FRDHVRTHTG EKPCQCKHCG KAFTCYSSLR EHGRTHSGEK PYECKECGKA FRYPSSLRAH MRMHTGEKPY VCKQCGKAFG CPTYFRRHVK THSGVKPYQC KECGKAYSFS SSLRIHVRTH TGEKPFECKH CGKAFSCHSS LREHVRTHSG EKPYECNQCG KAFSHAQYFQ KHVRSHSGVK PYECTECGKA YSCSSSLRVH VRTHTGERPY ECKQCGKTFR YLASLQAHVR THAGA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards