About Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETFDH) is a protein
from Homo sapiens identified by UniProt accession
Q16134, 617 residues long.
MolForge cross-references it against 0 known binders and
159 disease associations.
Target properties
| Protein name | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial |
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| UniProt accession | Q16134 |
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| Gene | ETFDH |
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| Organism | Homo sapiens |
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| Length | 617 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (159)
Diseases linked to this target (Open Targets).
- multiple acyl-CoA dehydrogenase deficiency · score 0.83
- Elevated circulating glutaric acid concentration · score 0.70
- Glutaric aciduria · score 0.58
- genetic disorder · score 0.48
- Abnormality of metabolism/homeostasis · score 0.41
- multiple acyl-CoA dehydrogenase deficiency, severe neonatal type · score 0.37
- multiple acyl-CoA dehydrogenase deficiency, mild type · score 0.37
- hypertrophic cardiomyopathy · score 0.26
- serum metabolite measurement · score 0.23
- blood protein measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16134-F1 | alphafold | PREDICTED | 93.59 | — |
Amino-acid sequence (617 residues)
MLVPLAKLSC LAYQCFHALK IKKNYLPLCA TRWSSTSTVP RITTHYTIYP RDKDKRWEGV NMERFAEEAD VVIVGAGPAG LSAAVRLKQL AVAHEKDIRV CLVEKAAQIG AHTLSGACLD PGAFKELFPD WKEKGAPLNT PVTEDRFGIL TEKYRIPVPI LPGLPMNNHG NYIVRLGHLV SWMGEQAEAL GVEVYPGYAA AEVLFHDDGS VKGIATNDVG IQKDGAPKAT FERGLELHAK VTIFAEGCHG HLAKQLYKKF DLRANCEPQT YGIGLKELWV IDEKNWKPGR VDHTVGWPLD RHTYGGSFLY HLNEGEPLVA LGLVVGLDYQ NPYLSPFREF QRWKHHPSIR PTLEGGKRIA YGARALNEGG FQSIPKLTFP GGLLIGCSPG FMNVPKIKGT HTAMKSGILA AESIFNQLTS ENLQSKTIGL HVTEYEDNLK NSWVWKELYS VRNIRPSCHG VLGVYGGMIY TGIFYWILRG MEPWTLKHKG SDFERLKPAK DCTPIEYPKP DGQISFDLLS SVALSGTNHE HDQPAHLTLR DDSIPVNRNL SIYDGPEQRF CPAGVYEFVP VEQGDGFRLQ INAQNCVHCK TCDIKDPSQN INWVVPEGGG GPAYNGM
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