Coiled-coil domain-containing protein 6 (CCDC6)

About Coiled-coil domain-containing protein 6

Coiled-coil domain-containing protein 6 (CCDC6) is a protein from Homo sapiens identified by UniProt accession Q16204, 474 residues long. MolForge cross-references it against 0 known binders and 208 disease associations.

Target properties

Protein name	Coiled-coil domain-containing protein 6
UniProt accession	Q16204
Gene	CCDC6
Organism	Homo sapiens
Length	474 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (208)

Diseases linked to this target (Open Targets).

non-small cell lung carcinoma · score 0.65
medullary thyroid gland carcinoma · score 0.58
neurodegenerative disease · score 0.53
neoplasm · score 0.50
thyroid neoplasm · score 0.46
papillary thyroid carcinoma · score 0.39
thyroid cancer · score 0.39
follicular thyroid carcinoma · score 0.39
serum albumin measurement · score 0.39
systolic blood pressure · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16204-F1	alphafold	PREDICTED	73.75	—

Amino-acid sequence (474 residues)

MADSASESDT DGAGGNSSSS AAMQSSCSST SGGGGGGGGG GGGGKSGGIV ISPFRLEELT NRLASLQQEN KVLKIELETY KLKCKALQEE NRDLRKASVT IQARAEQEEE FISNTLFKKI QALQKEKETL AVNYEKEEEF LTNELSRKLM QLQHEKAELE QHLEQEQEFQ VNKLMKKIKK LENDTISKQL TLEQLRREKI DLENTLEQEQ EALVNRLWKR MDKLEAEKRI LQEKLDQPVS APPSPRDISM EIDSPENMMR HIRFLKNEVE RLKKQLRAAQ LQHSEKMAQY LEEERHMREE NLRLQRKLQR EMERREALCR QLSESESSLE MDDERYFNEM SAQGLRPRTV SSPIPYTPSP SSSRPISPGL SYASHTVGFT PPTSLTRAGM SYYNSPGLHV QHMGTSHGIT RPSPRRSNSP DKFKRPTPPP SPNTQTPVQP PPPPPPPPMQ PTVPSAATSQ PTPSQHSAHP SSQP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards