About Ecto-NOX disulfide-thiol exchanger 2
Ecto-NOX disulfide-thiol exchanger 2 (ENOX2) is a protein
from Homo sapiens identified by UniProt accession
Q16206, 610 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Ecto-NOX disulfide-thiol exchanger 2 |
|---|
| UniProt accession | Q16206 |
|---|
| Gene | ENOX2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 610 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (38)
Diseases linked to this target (Open Targets).
- chronic myelogenous leukemia · score 0.07
- cancer · score 0.07
- neoplasm · score 0.03
- Malignant Mesothelioma · score 0.03
- mesothelioma · score 0.03
- mucous membrane pemphigoid · score 0.03
- melanoma · score 0.02
- urinary bladder carcinoma · score 0.02
- age at menarche · score 0.02
- age at voice drop · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16206-F1 | alphafold | PREDICTED | 77.06 | — |
Amino-acid sequence (610 residues)
MQRDFRWLWV YEIGYAADNS RTLNVDSTAM TLPMSDPTAW ATAMNNLGMA PLGIAGQPIL PDFDPALGMM TGIPPITPMM PGLGIVPPPI PPDMPVVKEI IHCKSCTLFP PNPNLPPPAT RERPPGCKTV FVGGLPENGT EQIIVEVFEQ CGEIIAIRKS KKNFCHIRFA EEYMVDKALY LSGYRIRLGS STDKKDTGRL HVDFAQARDD LYEWECKQRM LAREERHRRR MEEERLRPPS PPPVVHYSDH ECSIVAEKLK DDSKFSEAVQ TLLTWIERGE VNRRSANNFY SMIQSANSHV RRLVNEKAAH EKDMEEAKEK FKQALSGILI QFEQIVAVYH SASKQKAWDH FTKAQRKNIS VWCKQAEEIR NIHNDELMGI RREEEMEMSD DEIEEMTETK ETEESALVSQ AEALKEENDS LRWQLDAYRN EVELLKQEQG KVHREDDPNK EQQLKLLQQA LQGMQQHLLK VQEEYKKKEA ELEKLKDDKL QVEKMLENLK EKESCASRLC ASNQDSEYPL EKTMNSSPIK SEREALLVGI ISTFLHVHPF GASIEYICSY LHRLDNKICT SDVECLMGRL QHTFKQEMTG VGASLEKRWK FCGFEGLKLT
Explore Ecto-NOX disulfide-thiol exchanger 2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets