About UDP-N-acetylhexosamine pyrophosphorylase
UDP-N-acetylhexosamine pyrophosphorylase (UAP1) is a protein
from Homo sapiens identified by UniProt accession
Q16222, 522 residues long.
MolForge cross-references it against 0 known binders and
138 disease associations.
Target properties
| Protein name | UDP-N-acetylhexosamine pyrophosphorylase |
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| UniProt accession | Q16222 |
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| Gene | UAP1 |
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| Organism | Homo sapiens |
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| Length | 522 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (138)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- urate measurement · score 0.10
- early-onset non-syndromic cataract · score 0.10
- isolated ectopia lentis · score 0.08
- hereditary hyperferritinemia with congenital cataracts · score 0.08
- blood protein measurement · score 0.08
- Total congenital cataract · score 0.08
- Posterior polar cataract · score 0.08
- breast cancer · score 0.07
- Cataract-microcornea syndrome · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16222-F1 | alphafold | PREDICTED | 93.13 | — |
Amino-acid sequence (522 residues)
MNINDLKLTL SKAGQEHLLR FWNELEEAQQ VELYAELQAM NFEELNFFFQ KAIEGFNQSS HQKNVDARME PVPREVLGSA TRDQDQLQAW ESEGLFQISQ NKVAVLLLAG GQGTRLGVAY PKGMYDVGLP SRKTLFQIQA ERILKLQQVA EKYYGNKCII PWYIMTSGRT MESTKEFFTK HKYFGLKKEN VIFFQQGMLP AMSFDGKIIL EEKNKVSMAP DGNGGLYRAL AAQNIVEDME QRGIWSIHVY CVDNILVKVA DPRFIGFCIQ KGADCGAKVV EKTNPTEPVG VVCRVDGVYQ VVEYSEISLA TAQKRSSDGR LLFNAGNIAN HFFTVPFLRD VVNVYEPQLQ HHVAQKKIPY VDTQGQLIKP DKPNGIKMEK FVFDIFQFAK KFVVYEVLRE DEFSPLKNAD SQNGKDNPTT ARHALMSLHH CWVLNAGGHF IDENGSRLPA IPRSATNGKS ETITADVNHN LKDANDVPIQ CEISPLISYA GEGLESYVAD KEFHAPLIID ENGVHELVKN GI
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