Insulin-like growth factor-binding protein 7 (IGFBP7)

About Insulin-like growth factor-binding protein 7

Insulin-like growth factor-binding protein 7 (IGFBP7) is a protein from Homo sapiens identified by UniProt accession Q16270, 282 residues long. MolForge cross-references it against 0 known binders and 421 disease associations.

Target properties

Protein name	Insulin-like growth factor-binding protein 7
UniProt accession	Q16270
Gene	IGFBP7
Organism	Homo sapiens
Length	282 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (421)

Diseases linked to this target (Open Targets).

familial retinal arterial macroaneurysm · score 0.60
blood protein measurement · score 0.42
low density lipoprotein cholesterol measurement · score 0.42
heel bone mineral density · score 0.38
insulin-like growth factor-binding protein 7 measurement · score 0.35
apolipoprotein A 1 measurement · score 0.34
diastolic blood pressure · score 0.34
apolipoprotein B measurement · score 0.34
sleep duration · score 0.34
refractive error · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16270-F1	alphafold	PREDICTED	84.44	—

Amino-acid sequence (282 residues)

MERPSLRALL LGAAGLLLLL LPLSSSSSSD TCGPCEPASC PPLPPLGCLL GETRDACGCC PMCARGEGEP CGGGGAGRGY CAPGMECVKS RKRRKGKAGA AAGGPGVSGV CVCKSRYPVC GSDGTTYPSG CQLRAASQRA ESRGEKAITQ VSKGTCEQGP SIVTPPKDIW NVTGAQVYLS CEVIGIPTPV LIWNKVKRGH YGVQRTELLP GDRDNLAIQT RGGPEKHEVT GWVLVSPLSK EDAGEYECHA SNSQGQASAS AKITVVDALH EIPVKKGEGA EL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards