About Cyclic nucleotide-gated channel alpha-3
Cyclic nucleotide-gated channel alpha-3 (CNGA3) is a protein
from Homo sapiens identified by UniProt accession
Q16281, 694 residues long.
MolForge cross-references it against 0 known binders and
76 disease associations.
Target properties
| Protein name | Cyclic nucleotide-gated channel alpha-3 |
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| UniProt accession | Q16281 |
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| Gene | CNGA3 |
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| Organism | Homo sapiens |
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| Length | 694 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (76)
Diseases linked to this target (Open Targets).
- achromatopsia · score 0.73
- Retinal dystrophy · score 0.55
- Cone rod dystrophy · score 0.54
- cone dystrophy · score 0.48
- cone-rod dystrophy · score 0.44
- Abnormality of the eye · score 0.43
- genetic disorder · score 0.38
- junctional epidermolysis bullosa Herlitz type · score 0.34
- Krabbe disease · score 0.34
- Fabry disease · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16281-F1 | alphafold | PREDICTED | 74.42 | — |
Amino-acid sequence (694 residues)
MAKINTQYSH PSRTHLKVKT SDRDLNRAEN GLSRAHSSSE ETSSVLQPGI AMETRGLADS GQGSFTGQGI ARLSRLIFLL RRWAARHVHH QDQGPDSFPD RFRGAELKEV SSQESNAQAN VGSQEPADRG RSAWPLAKCN TNTSNNTEEE KKTKKKDAIV VDPSSNLYYR WLTAIALPVF YNWYLLICRA CFDELQSEYL MLWLVLDYSA DVLYVLDVLV RARTGFLEQG LMVSDTNRLW QHYKTTTQFK LDVLSLVPTD LAYLKVGTNY PEVRFNRLLK FSRLFEFFDR TETRTNYPNM FRIGNLVLYI LIIIHWNACI YFAISKFIGF GTDSWVYPNI SIPEHGRLSR KYIYSLYWST LTLTTIGETP PPVKDEEYLF VVVDFLVGVL IFATIVGNVG SMISNMNASR AEFQAKIDSI KQYMQFRKVT KDLETRVIRW FDYLWANKKT VDEKEVLKSL PDKLKAEIAI NVHLDTLKKV RIFQDCEAGL LVELVLKLRP TVFSPGDYIC KKGDIGKEMY IINEGKLAVV ADDGVTQFVV LSDGSYFGEI SILNIKGSKS GNRRTANIRS IGYSDLFCLS KDDLMEALTE YPEAKKALEE KGRQILMKDN LIDEELARAG ADPKDLEEKV EQLGSSLDTL QTRFARLLAE YNATQMKMKQ RLSQLESQVK GGGDKPLADG EVPGDATKTE DKQQ
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