About Potassium voltage-gated channel subfamily A member 10
Potassium voltage-gated channel subfamily A member 10 (KCNA10) is a protein
from Homo sapiens identified by UniProt accession
Q16322, 511 residues long.
MolForge cross-references it against 0 known binders and
72 disease associations.
Target properties
| Protein name | Potassium voltage-gated channel subfamily A member 10 |
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| UniProt accession | Q16322 |
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| Gene | KCNA10 |
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| Organism | Homo sapiens |
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| Length | 511 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (72)
Diseases linked to this target (Open Targets).
- multiple sclerosis · score 0.59
- Myasthenia gravis · score 0.57
- Muscle weakness · score 0.46
- small cell carcinoma · score 0.46
- secondary progressive multiple sclerosis · score 0.43
- anterior ischemic optic neuropathy · score 0.37
- primary progressive multiple sclerosis · score 0.37
- transverse myelitis · score 0.37
- atrial fibrillation · score 0.35
- atrial flutter · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16322-F1 | alphafold | PREDICTED | 76.83 | — |
Amino-acid sequence (511 residues)
MDVCGWKEME VALVNFDNSD EIQEEPGYAT DFDSTSPKGR PGGSSFSNGK ILISESTNHE TAFSKLPGDY ADPPGPEPVV LNEGNQRVII NIAGLRFETQ LRTLSQFPET LLGDREKRMQ FFDSMRNEYF FDRNRPSFDG ILYYYQSGGK IRRPANVPID IFADEISFYE LGSEAMDQFR EDEGFIKDPE TLLPTNDIHR QFWLLFEYPE SSSAARAVAV VSVLVVVISI TIFCLETLPE FREDRELKVV RDPNLNMSKT VLSQTMFTDP FFMVESTCIV WFTFELVLRF VVCPSKTDFF RNIMNIIDII SIIPYFATLI TELVQETEPS AQQNMSLAIL RIIRLVRVFR IFKLSRHSKG LQILGQTLKA SMRELGLLIF FLFIGVILFS SAVYFAEVDE PESHFSSIPD GFWWAVVTMT TVGYGDMCPT TPGGKIVGTL CAIAGVLTIA LPVPVIVSNF NYFYHRETEN EEKQNIPGEI ERILNSVGSR MGSTDSLNKT NGGCSTEKSR K
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