uS5 assembly chaperone PDCD2 (PDCD2)

About uS5 assembly chaperone PDCD2

uS5 assembly chaperone PDCD2 (PDCD2) is a protein from Homo sapiens identified by UniProt accession Q16342, 344 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.

Target properties

Protein name	uS5 assembly chaperone PDCD2
UniProt accession	Q16342
Gene	PDCD2
Organism	Homo sapiens
Length	344 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (59)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.52
hepatocellular carcinoma · score 0.18
blood protein measurement · score 0.10
chromosome 22q11.2 microduplication syndrome · score 0.07
jaw-winking syndrome · score 0.06
Congenital ptosis · score 0.06
ptosis, hereditary congenital, 1 · score 0.06
cancer · score 0.05
syndromic orbital border hypoplasia · score 0.05
protein measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16342-F1	alphafold	PREDICTED	84.79	—

Amino-acid sequence (344 residues)

MAAAGARPVE LGFAESAPAW RLRSEQFPSK VGGRPAWLGA AGLPGPQALA CELCGRPLSF LLQVYAPLPG RPDAFHRCIF LFCCREQPCC AGLRVFRNQL PRKNDFYSYE PPSENPPPET GESVCLQLKS GAHLCRVCGC LGPKTCSRCH KAYYCSKEHQ TLDWRLGHKQ ACAQPDHLDH IIPDHNFLFP EFEIVIETED EIMPEVVEKE DYSEIIGSMG EALEEELDSM AKHESREDKI FQKFKTQIAL EPEQILRYGR GIAPIWISGE NIPQEKDIPD CPCGAKRILE FQVMPQLLNY LKADRLGKSI DWGILAVFTC AESCSLGTGY TEEFVWKQDV TDTP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards