Alpha-internexin (INA)

About Alpha-internexin

Alpha-internexin (INA) is a protein from Homo sapiens identified by UniProt accession Q16352, 499 residues long. MolForge cross-references it against 0 known binders and 135 disease associations.

Target properties

Protein name	Alpha-internexin
UniProt accession	Q16352
Gene	INA
Organism	Homo sapiens
Length	499 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (135)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
Abnormal brain morphology · score 0.27
cortical surface area measurement · score 0.21
blood phosphate measurement · score 0.19
glomerular filtration rate · score 0.17
pulse pressure measurement · score 0.15
thalamus volume · score 0.11
Myopia · score 0.11
pathological myopia · score 0.11
brain volume measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16352-F1	alphafold	PREDICTED	74.06	—

Amino-acid sequence (499 residues)

MSFGSEHYLC SSSSYRKVFG DGSRLSARLS GAGGAGGFRS QSLSRSNVAS SAACSSASSL GLGLAYRRPP ASDGLDLSQA AARTNEYKII RTNEKEQLQG LNDRFAVFIE KVHQLETQNR ALEAELAALR QRHAEPSRVG ELFQRELRDL RAQLEEASSA RSQALLERDG LAEEVQRLRA RCEEESRGRE GAERALKAQQ RDVDGATLAR LDLEKKVESL LDELAFVRQV HDEEVAELLA TLQASSQAAA EVDVTVAKPD LTSALREIRA QYESLAAKNL QSAEEWYKSK FANLNEQAAR STEAIRASRE EIHEYRRQLQ ARTIEIEGLR GANESLERQI LELEERHSAE VAGYQDSIGQ LENDLRNTKS EMARHLREYQ DLLNVKMALD IEIAAYRKLL EGEETRFSTS GLSISGLNPL PNPSYLLPPR ILSATTSKVS STGLSLKKEE EEEEASKVAS KKTSQIGESF EEILEETVIS TKKTEKSNIE ETTISSQKI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards