26S proteasome non-ATPase regulatory subunit 5 (PSMD5)

About 26S proteasome non-ATPase regulatory subunit 5

26S proteasome non-ATPase regulatory subunit 5 (PSMD5) is a protein from Homo sapiens identified by UniProt accession Q16401, 504 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	26S proteasome non-ATPase regulatory subunit 5
UniProt accession	Q16401
Gene	PSMD5
Organism	Homo sapiens
Length	504 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

HIV infection · score 0.46
platelet count · score 0.40
sex hormone-binding globulin measurement · score 0.39
alkaline phosphatase measurement · score 0.30
breast adenocarcinoma · score 0.30
low grade glioma · score 0.29
endometrial cancer · score 0.29
systolic blood pressure · score 0.29
esophageal cancer · score 0.28
urinary bladder cancer · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16401-F1	alphafold	PREDICTED	93.81	—

Amino-acid sequence (504 residues)

MAAQALALLR EVARLEAPLE ELRALHSVLQ AVPLNELRQQ AAELRLGPLF SLLNENHREK TTLCVSILER LLQAMEPVHV ARNLRVDLQR GLIHPDDSVK ILTLSQIGRI VENSDAVTEI LNNAELLKQI VYCIGGENLS VAKAAIKSLS RISLTQAGLE ALFESNLLDD LKSVMKTNDI VRYRVYELII EISSVSPESL NYCTTSGLVT QLLRELTGED VLVRATCIEM VTSLAYTHHG RQYLAQEGVI DQISNIIVGA DSDPFSSFYL PGFVKFFGNL AVMDSPQQIC ERYPIFVEKV FEMIESQDPT MIGVAVDTVG ILGSNVEGKQ VLQKTGTRFE RLLMRIGHQS KNAPVELKIR CLDAISSLLY LPPEQQTDDL LRMTESWFSS LSRDPLELFR GISSQPFPEL HCAALKVFTA IANQPWAQKL MFNSPGFVEY VVDRSVEHDK ASKDAKYELV KALANSKTIA EIFGNPNYLR LRTYLSEGPY YVKPVSTTAV EGAE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards