About Gamma-aminobutyric acid receptor subunit alpha-6
Gamma-aminobutyric acid receptor subunit alpha-6 (GABRA6) is a protein
from Homo sapiens identified by UniProt accession
Q16445, 453 residues long.
MolForge cross-references it against 0 known binders and
246 disease associations.
Target properties
| Protein name | Gamma-aminobutyric acid receptor subunit alpha-6 |
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| UniProt accession | Q16445 |
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| Gene | GABRA6 |
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| Organism | Homo sapiens |
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| Length | 453 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (246)
Diseases linked to this target (Open Targets).
- Seizure · score 0.61
- epilepsy · score 0.60
- pain · score 0.60
- alcohol dependence · score 0.60
- migraine disorder · score 0.60
- delirium · score 0.59
- obesity · score 0.58
- coronary artery disease · score 0.58
- Agitation · score 0.57
- depressive disorder · score 0.57
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16445-F1 | alphafold | PREDICTED | 82.07 | — |
Amino-acid sequence (453 residues)
MASSLPWLCI ILWLENALGK LEVEGNFYSE NVSRILDNLL EGYDNRLRPG FGGAVTEVKT DIYVTSFGPV SDVEMEYTMD VFFRQTWTDE RLKFGGPTEI LSLNNLMVSK IWTPDTFFRN GKKSIAHNMT TPNKLFRIMQ NGTILYTMRL TINADCPMRL VNFPMDGHAC PLKFGSYAYP KSEIIYTWKK GPLYSVEVPE ESSSLLQYDL IGQTVSSETI KSNTGEYVIM TVYFHLQRKM GYFMIQIYTP CIMTVILSQV SFWINKESVP ARTVFGITTV LTMTTLSISA RHSLPKVSYA TAMDWFIAVC FAFVFSALIE FAAVNYFTNL QTQKAKRKAQ FAAPPTVTIS KATEPLEAEI VLHPDSKYHL KKRITSLSLP IVSSSEANKV LTRAPILQST PVTPPPLSPA FGGTSKIDQY SRILFPVAFA GFNLVYWVVY LSKDTMEVSS SVE
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