Transcription initiation factor TFIID subunit 12…

About Transcription initiation factor TFIID subunit 12

Transcription initiation factor TFIID subunit 12 (TAF12) is a protein from Homo sapiens identified by UniProt accession Q16514, 161 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.

Target properties

Protein name	Transcription initiation factor TFIID subunit 12
UniProt accession	Q16514
Gene	TAF12
Organism	Homo sapiens
Length	161 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (29)

Diseases linked to this target (Open Targets).

HIV infection · score 0.58
neurodegenerative disease · score 0.25
ovarian cancer · score 0.23
hemoglobin measurement · score 0.06
isolated spina bifida · score 0.05
anencephaly 1 · score 0.05
spina bifida-hypospadias syndrome · score 0.05
lymphocyte count · score 0.04
tropical spastic paraparesis · score 0.04
Isolated anencephaly/exencephaly · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16514-F1	alphafold	PREDICTED	76.45	—

Amino-acid sequence (161 residues)

MNQFGPSALI NLSNFSSIKP EPASTPPQGS MANSTAVVKI PGTPGAGGRL SPENNQVLTK KKLQDLVREV DPNEQLDEDV EEMLLQIADD FIESVVTAAC QLARHRKSST LEVKDVQLHL ERQWNMWIPG FGSEEIRPYK KACTTEAHKQ RMALIRKTTK K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Transcription initiation factor TFIID subunit 12 (TAF12)