About Acid-sensing ion channel 2
Acid-sensing ion channel 2 (ASIC2) is a protein
from Homo sapiens identified by UniProt accession
Q16515, 512 residues long.
MolForge cross-references it against 0 known binders and
172 disease associations.
Target properties
| Protein name | Acid-sensing ion channel 2 |
|---|
| UniProt accession | Q16515 |
|---|
| Gene | ASIC2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 512 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (172)
Diseases linked to this target (Open Targets).
- body mass index · score 0.41
- lean body mass · score 0.34
- monocyte count · score 0.34
- fat body mass · score 0.32
- blood protein measurement · score 0.32
- puberty onset measurement · score 0.32
- self reported educational attainment · score 0.30
- mathematical ability · score 0.29
- monocyte percentage of leukocytes · score 0.29
- PHF-tau measurement · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16515-F1 | alphafold | PREDICTED | 86.48 | — |
Amino-acid sequence (512 residues)
MDLKESPSEG SLQPSSIQIF ANTSTLHGIR HIFVYGPLTI RRVLWAVAFV GSLGLLLVES SERVSYYFSY QHVTKVDEVV AQSLVFPAVT LCNLNGFRFS RLTTNDLYHA GELLALLDVN LQIPDPHLAD PSVLEALRQK ANFKHYKPKQ FSMLEFLHRV GHDLKDMMLY CKFKGQECGH QDFTTVFTKY GKCYMFNSGE DGKPLLTTVK GGTGNGLEIM LDIQQDEYLP IWGETEETTF EAGVKVQIHS QSEPPFIQEL GFGVAPGFQT FVATQEQRLT YLPPPWGECR SSEMGLDFFP VYSITACRID CETRYIVENC NCRMVHMPGD APFCTPEQHK ECAEPALGLL AEKDSNYCLC RTPCNLTRYN KELSMVKIPS KTSAKYLEKK FNKSEKYISE NILVLDIFFE ALNYETIEQK KAYEVAALLG DIGGQMGLFI GASILTILEL FDYIYELIKE KLLDLLGKEE DEGSHDENVS TCDTMPNHSE TISHTVNVPL QTTLGTLEEI AC
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