Retinoid isomerohydrolase (RPE65)

About Retinoid isomerohydrolase

Retinoid isomerohydrolase (RPE65) is a protein from Homo sapiens identified by UniProt accession Q16518, 533 residues long. MolForge cross-references it against 0 known binders and 260 disease associations.

Target properties

Protein name	Retinoid isomerohydrolase
UniProt accession	Q16518
Gene	RPE65
Organism	Homo sapiens
Length	533 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (260)

Diseases linked to this target (Open Targets).

Leber congenital amaurosis 2 · score 0.83
Leber congenital amaurosis · score 0.76
retinitis pigmentosa · score 0.73
RPE65-related recessive retinopathy · score 0.68
Retinal dystrophy · score 0.62
autosomal recessive retinitis pigmentosa · score 0.51
genetic disorder · score 0.47
Abnormality of the eye · score 0.41
Cone rod dystrophy · score 0.40
severe early-childhood-onset retinal dystrophy · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16518-F1	alphafold	PREDICTED	95.43	—

Amino-acid sequence (533 residues)

MSIQVEHPAG GYKKLFETVE ELSSPLTAHV TGRIPLWLTG SLLRCGPGLF EVGSEPFYHL FDGQALLHKF DFKEGHVTYH RRFIRTDAYV RAMTEKRIVI TEFGTCAFPD PCKNIFSRFF SYFRGVEVTD NALVNVYPVG EDYYACTETN FITKINPETL ETIKQVDLCN YVSVNGATAH PHIENDGTVY NIGNCFGKNF SIAYNIVKIP PLQADKEDPI SKSEIVVQFP CSDRFKPSYV HSFGLTPNYI VFVETPVKIN LFKFLSSWSL WGANYMDCFE SNETMGVWLH IADKKRKKYL NNKYRTSPFN LFHHINTYED NGFLIVDLCC WKGFEFVYNY LYLANLRENW EEVKKNARKA PQPEVRRYVL PLNIDKADTG KNLVTLPNTT ATAILCSDET IWLEPEVLFS GPRQAFEFPQ INYQKYCGKP YTYAYGLGLN HFVPDRLCKL NVKTKETWVW QEPDSYPSEP IFVSHPDALE EDDGVVLSVV VSPGAGQKPA YLLILNAKDL SEVARAEVEI NIPVTFHGLF KKS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards