Basic leucine zipper transcriptional factor…

About Basic leucine zipper transcriptional factor ATF-like

Basic leucine zipper transcriptional factor ATF-like (BATF) is a protein from Homo sapiens identified by UniProt accession Q16520, 125 residues long. MolForge cross-references it against 0 known binders and 290 disease associations.

Target properties

Protein name	Basic leucine zipper transcriptional factor ATF-like
UniProt accession	Q16520
Gene	BATF
Organism	Homo sapiens
Length	125 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (290)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.42
eosinophil count · score 0.39
multiple sclerosis · score 0.35
neutrophil percentage of leukocytes · score 0.34
eosinophil percentage of leukocytes · score 0.33
wet macular degeneration · score 0.32
neurodegenerative disease · score 0.29
lymphocyte percentage of leukocytes · score 0.29
leukocyte count · score 0.28
neutrophil-to-lymphocyte ratio · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16520-F1	alphafold	PREDICTED	80.69	—

Amino-acid sequence (125 residues)

MPHSSDSSDS SFSRSPPPGK QDSSDDVRRV QRREKNRIAA QKSRQRQTQK ADTLHLESED LEKQNAALRK EIKQLTEELK YFTSVLNSHE PLCSVLAAST PSPPEVVYSA HAFHQPHVSS PRFQP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Basic leucine zipper transcriptional factor ATF-like (BATF)