About Hepatic leukemia factor
Hepatic leukemia factor (HLF) is a protein
from Homo sapiens identified by UniProt accession
Q16534, 295 residues long.
MolForge cross-references it against 0 known binders and
137 disease associations.
Target properties
| Protein name | Hepatic leukemia factor |
|---|
| UniProt accession | Q16534 |
|---|
| Gene | HLF |
|---|
| Organism | Homo sapiens |
|---|
| Length | 295 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (137)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.49
- erythrocyte count · score 0.43
- testosterone measurement · score 0.40
- uric acid measurement · score 0.39
- hemoglobin measurement · score 0.39
- IGF-1 measurement · score 0.38
- kidney neoplasm · score 0.37
- lymphoid neoplasm · score 0.37
- esophageal adenocarcinoma · score 0.37
- bile duct carcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16534-F1 | alphafold | PREDICTED | 71.77 | — |
Amino-acid sequence (295 residues)
MEKMSRPLPL NPTFIPPPYG VLRSLLENPL KLPLHHEDAF SKDKDKEKKL DDESNSPTVP QSAFLGPTLW DKTLPYDGDT FQLEYMDLEE FLSENGIPPS PSQHDHSPHP PGLQPASSAA PSVMDLSSRA SAPLHPGIPS PNCMQSPIRP GQLLPANRNT PSPIDPDTIQ VPVGYEPDPA DLALSSIPGQ EMFDPRKRKF SEEELKPQPM IKKARKVFIP DDLKDDKYWA RRRKNNMAAK RSRDARRLKE NQIAIRASFL EKENSALRQE VADLRKELGK CKNILAKYEA RHGPL
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