About Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PPP2R5E) is a protein
from Homo sapiens identified by UniProt accession
Q16537, 467 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform |
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| UniProt accession | Q16537 |
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| Gene | PPP2R5E |
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| Organism | Homo sapiens |
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| Length | 467 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (53)
Diseases linked to this target (Open Targets).
- cancer · score 0.53
- systolic blood pressure · score 0.38
- chronic myelogenous leukemia · score 0.37
- glioblastoma multiforme · score 0.30
- breast adenocarcinoma · score 0.29
- endometrial cancer · score 0.29
- lung adenocarcinoma · score 0.28
- cortical surface area measurement · score 0.26
- neurodegenerative disease · score 0.26
- lysosomal storage disease · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16537-F1 | alphafold | PREDICTED | 88.64 | — |
Amino-acid sequence (467 residues)
MSSAPTTPPS VDKVDGFSRK SVRKARQKRS QSSSQFRSQG KPIELTPLPL LKDVPSSEQP ELFLKKLQQC CVIFDFMDTL SDLKMKEYKR STLNELVDYI TISRGCLTEQ TYPEVVRMVS CNIFRTLPPS DSNEFDPEED EPTLEASWPH LQLVYEFFIR FLESQEFQPS IAKKYIDQKF VLQLLELFDS EDPRERDYLK TVLHRIYGKF LGLRAFIRKQ INNIFLRFVY ETEHFNGVAE LLEILGSIIN GFALPLKAEH KQFLVKVLIP LHTVRSLSLF HAQLAYCIVQ FLEKDPSLTE PVIRGLMKFW PKTCSQKEVM FLGELEEILD VIEPSQFVKI QEPLFKQIAK CVSSPHFQVA ERALYYWNNE YIMSLIEENS NVILPIMFSS LYRISKEHWN PAIVALVYNV LKAFMEMNST MFDELTATYK SDRQREKKKE KEREELWKKL EDLELKRGLR RDGIIPT
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