About Probable G-protein coupled receptor 162
Probable G-protein coupled receptor 162 (GPR162) is a protein
from Homo sapiens identified by UniProt accession
Q16538, 588 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | Probable G-protein coupled receptor 162 |
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| UniProt accession | Q16538 |
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| Gene | GPR162 |
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| Organism | Homo sapiens |
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| Length | 588 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (20)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- blood protein measurement · score 0.10
- sex hormone-binding globulin measurement · score 0.09
- neoplasm · score 0.07
- leukocyte count · score 0.07
- serum gamma-glutamyl transferase measurement · score 0.05
- hip bone mineral density · score 0.04
- Sepsis · score 0.03
- cancer · score 0.03
- insulin resistance · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16538-F1 | alphafold | PREDICTED | 63.97 | — |
Amino-acid sequence (588 residues)
MARGGAGAEE ASLRSNALSW LACGLLALLA NAWIILSISA KQQKHKPLEL LLCFLAGTHI LMAAVPLTTF AVVQLRRQAS SDYDWNESIC KVFVSTYYTL ALATCFTVAS LSYHRMWMVR WPVNYRLSNA KKQALHAVMG IWMVSFILST LPSIGWHNNG ERYYARGCQF IVSKIGLGFG VCFSLLLLGG IVMGLVCVAI TFYQTLWARP RRARQARRVG GGGGTKAGGP GALGTRPAFE VPAIVVEDAR GKRRSSLDGS ESAKTSLQVT NLVSAIVFLY DSLTGVPILV VSFFSLKSDS APPWMVLAVL WCSMAQTLLL PSFIWSCERY RADVRTVWEQ CVAIMSEEDG DDDGGCDDYA EGRVCKVRFD ANGATGPGSR DPAQVKLLPG RHMLFPPLER VHYLQVPLSR RLSHDETNIF STPREPGSFL HKWSSSDDIR VLPAQSRALG GPPEYLGQRH RLEDEEDEEE AEGGGLASLR QFLESGVLGS GGGPPRGPGF FREEITTFID ETPLPSPTAS PGHSPRRPRP LGLSPRRLSL GSPESRAVGL PLGLSAGRRC SLTGGEESAR AWGGSWGPGN PIFPQLTL
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