Hsp90 co-chaperone Cdc37 (CDC37)

About Hsp90 co-chaperone Cdc37

Hsp90 co-chaperone Cdc37 (CDC37) is a protein from Homo sapiens identified by UniProt accession Q16543, 378 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.

Target properties

Protein name	Hsp90 co-chaperone Cdc37
UniProt accession	Q16543
Gene	CDC37
Organism	Homo sapiens
Length	378 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (93)

Diseases linked to this target (Open Targets).

cancer · score 0.61
glioblastoma multiforme · score 0.28
lung adenocarcinoma · score 0.28
head and neck squamous cell carcinoma · score 0.28
breast adenocarcinoma · score 0.27
inflammatory bowel disease · score 0.27
cutaneous melanoma · score 0.26
Crohn's disease · score 0.24
leukocyte count · score 0.24
myeloid white cell count · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16543-F1	alphafold	PREDICTED	81.01	—

Amino-acid sequence (378 residues)

MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL DRGCRECKRK VAECQRKLKE LEVAEGGKAE LERLQAEAQQ LRKEERSWEQ KLEEMRKKEK SMPWNVDTLS KDGFSKSMVN TKPEKTEEDS EEVREQKHKT FVEKYEKQIK HFGMLRRWDD SQKYLSDNVH LVCEETANYL VIWCIDLEVE EKCALMEQVA HQTIVMQFIL ELAKSLKVDP RACFRQFFTK IKTADRQYME GFNDELEAFK ERVRGRAKLR IEKAMKEYEE EERKKRLGPG GLDPVEVYES LPEELQKCFD VKDVQMLQDA ISKMDPTDAK YHMQRCIDSG LWVPNSKASE AKEGEEAGPG DPLLEAVPKT GDEKDVSV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards