About Bcl-2-related protein A1
Bcl-2-related protein A1 (BCL2A1) is a protein
from Homo sapiens identified by UniProt accession
Q16548, 175 residues long.
MolForge cross-references it against 0 known binders and
277 disease associations.
Target properties
| Protein name | Bcl-2-related protein A1 |
|---|
| UniProt accession | Q16548 |
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| Gene | BCL2A1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 175 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (277)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.45
- eosinophil count · score 0.45
- leukocyte count · score 0.43
- myeloid white cell count · score 0.41
- monocyte percentage of leukocytes · score 0.39
- lymphocyte count · score 0.37
- lymphocyte:monocyte ratio · score 0.36
- eosinophil percentage of leukocytes · score 0.35
- small cell lung carcinoma · score 0.33
- granulocyte percentage of myeloid white cells · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16548-F1 | alphafold | PREDICTED | 87.29 | — |
Amino-acid sequence (175 residues)
MTDCEFGYIY RLAQDYLQCV LQIPQPGSGP SKTSRVLQNV AFSVQKEVEK NLKSCLDNVN VVSVDTARTL FNQVMEKEFE DGIINWGRIV TIFAFEGILI KKLLRQQIAP DVDTYKEISY FVAEFIMNNT GEWIRQNGGW ENGFVKKFEP KSGWMTFLEV TGKICEMLSL LKQYC
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