About Dihydropyrimidinase-related protein 2
Dihydropyrimidinase-related protein 2 (DPYSL2) is a protein
from Homo sapiens identified by UniProt accession
Q16555, 572 residues long.
MolForge cross-references it against 0 known binders and
206 disease associations.
Target properties
| Protein name | Dihydropyrimidinase-related protein 2 |
|---|
| UniProt accession | Q16555 |
|---|
| Gene | DPYSL2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 572 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (206)
Diseases linked to this target (Open Targets).
- brain measurement · score 0.39
- cortical surface area measurement · score 0.38
- autosomal dominant non-syndromic intellectual disability · score 0.37
- neuroimaging measurement · score 0.36
- body height · score 0.36
- diastolic blood pressure · score 0.35
- cortical thickness · score 0.34
- PHF-tau measurement · score 0.33
- facial morphology measurement · score 0.31
- esophageal adenocarcinoma · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16555-F1 | alphafold | PREDICTED | 90.25 | — |
Amino-acid sequence (572 residues)
MSYQGKKNIP RITSDRLLIK GGKIVNDDQS FYADIYMEDG LIKQIGENLI VPGGVKTIEA HSRMVIPGGI DVHTRFQMPD QGMTSADDFF QGTKAALAGG TTMIIDHVVP EPGTSLLAAF DQWREWADSK SCCDYSLHVD ISEWHKGIQE EMEALVKDHG VNSFLVYMAF KDRFQLTDCQ IYEVLSVIRD IGAIAQVHAE NGDIIAEEQQ RILDLGITGP EGHVLSRPEE VEAEAVNRAI TIANQTNCPL YITKVMSKSS AEVIAQARKK GTVVYGEPIT ASLGTDGSHY WSKNWAKAAA FVTSPPLSPD PTTPDFLNSL LSCGDLQVTG SAHCTFNTAQ KAVGKDNFTL IPEGTNGTEE RMSVIWDKAV VTGKMDENQF VAVTSTNAAK VFNLYPRKGR IAVGSDADLV IWDPDSVKTI SAKTHNSSLE YNIFEGMECR GSPLVVISQG KIVLEDGTLH VTEGSGRYIP RKPFPDFVYK RIKARSRLAE LRGVPRGLYD GPVCEVSVTP KTVTPASSAK TSPAKQQAPP VRNLHQSGFS LSGAQIDDNI PRRTTQRIVA PPGGRANITS LG
Explore Dihydropyrimidinase-related protein 2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets