About Pregnancy-specific beta-1-glycoprotein 3
Pregnancy-specific beta-1-glycoprotein 3 (PSG3) is a protein
from Homo sapiens identified by UniProt accession
Q16557, 428 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Pregnancy-specific beta-1-glycoprotein 3 |
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| UniProt accession | Q16557 |
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| Gene | PSG3 |
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| Organism | Homo sapiens |
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| Length | 428 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (53)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.18
- multiple myeloma · score 0.17
- thyroid gland adenocarcinoma · score 0.16
- head and neck squamous cell carcinoma · score 0.11
- venous thromboembolism · score 0.10
- obesity due to melanocortin 4 receptor deficiency · score 0.06
- LIPE-related familial partial lipodystrophy · score 0.04
- obesity due to leptin receptor gene deficiency · score 0.04
- AXIN2-related attenuated familial adenomatous polyposis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16557-F1 | alphafold | PREDICTED | 85.23 | — |
Amino-acid sequence (428 residues)
MGPLSAPPCT QRITWKGLLL TALLLNFWNL PTTAQVTIEA EPTKVSKGKD VLLLVHNLPQ NLAGYIWYKG QMKDLYHYIT SYVVDGQIII YGPAYSGRET VYSNASLLIQ NVTREDAGSY TLHIVKRGDG TRGETGHFTF TLYLETPKPS ISSSNLYPRE DMEAVSLTCD PETPDASYLW WMNGQSLPMT HSLQLSKNKR TLFLFGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLP KPYITINNLN PRENKDVLAF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPSV TRNETGPYQC EIQDRYGGIR SYPVTLNVLY GPDLPRIYPS FTYYHSGENL YLSCFADSNP PAEYSWTING KFQLSGQKLF IPQITTKHSG LYACSVRNSA TGMESSKSMT VKVSAPSGTG HLPGLNPL
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