About Calcium-activated potassium channel subunit beta-1
Calcium-activated potassium channel subunit beta-1 (KCNMB1) is a protein
from Homo sapiens identified by UniProt accession
Q16558, 191 residues long.
MolForge cross-references it against 0 known binders and
79 disease associations.
Target properties
| Protein name | Calcium-activated potassium channel subunit beta-1 |
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| UniProt accession | Q16558 |
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| Gene | KCNMB1 |
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| Organism | Homo sapiens |
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| Length | 191 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (79)
Diseases linked to this target (Open Targets).
- FEV/FVC ratio · score 0.41
- neurodegenerative disease · score 0.37
- neuroinflammatory disorder · score 0.18
- PHF-tau measurement · score 0.14
- viral load · score 0.12
- neurofibrillary tangles measurement · score 0.12
- protein measurement · score 0.10
- Moyamoya disease · score 0.05
- focal segmental glomerulosclerosis · score 0.05
- familial idiopathic steroid-resistant nephrotic syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16558-F1 | alphafold | PREDICTED | 84.11 | — |
Amino-acid sequence (191 residues)
MVKKLVMAQK RGETRALCLG VTMVVCAVIT YYILVTTVLP LYQKSVWTQE SKCHLIETNI RDQEELKGKK VPQYPCLWVN VSAAGRWAVL YHTEDTRDQN QQCSYIPGSV DNYQTARADV EKVRAKFQEQ QVFYCFSAPR GNETSVLFQR LYGPQALLFS LFWPTFLLTG GLLIIAMVKS NQYLSILAAQ K
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