T-cell acute lymphocytic leukemia protein 2 (TAL2)

About T-cell acute lymphocytic leukemia protein 2

T-cell acute lymphocytic leukemia protein 2 (TAL2) is a protein from Homo sapiens identified by UniProt accession Q16559, 108 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.

Target properties

Protein name	T-cell acute lymphocytic leukemia protein 2
UniProt accession	Q16559
Gene	TAL2
Organism	Homo sapiens
Length	108 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (87)

Diseases linked to this target (Open Targets).

Endometrial Endometrioid Adenocarcinoma · score 0.37
skin squamous cell carcinoma · score 0.37
Cervical Small Cell Carcinoma · score 0.37
breast carcinoma · score 0.29
neurofibrillary tangles measurement · score 0.29
hepatocellular carcinoma · score 0.28
lung adenocarcinoma · score 0.28
squamous cell lung carcinoma · score 0.28
cutaneous melanoma · score 0.28
gastric carcinoma · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16559-F1	alphafold	PREDICTED	77.86	—

Amino-acid sequence (108 residues)

MTRKIFTNTR ERWRQQNVNS AFAKLRKLIP THPPDKKLSK NETLRLAMRY INFLVKVLGE QSLQQTGVAA QGNILGLFPQ GPHLPGLEDR TLLENYQVPS PGPSHHIP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards