About Calcium/calmodulin-dependent protein kinase type IV
Calcium/calmodulin-dependent protein kinase type IV (CAMK4) is a protein
from Homo sapiens identified by UniProt accession
Q16566, 473 residues long.
MolForge cross-references it against 0 known binders and
304 disease associations.
Target properties
| Protein name | Calcium/calmodulin-dependent protein kinase type IV |
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| UniProt accession | Q16566 |
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| Gene | CAMK4 |
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| Organism | Homo sapiens |
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| Length | 473 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (304)
Diseases linked to this target (Open Targets).
- Intellectual disability · score 0.53
- lymphocyte count · score 0.46
- Autism · score 0.46
- Dystonia · score 0.46
- Ataxia · score 0.46
- Global developmental delay · score 0.46
- Atypical behavior · score 0.46
- autism · score 0.46
- chorea · score 0.46
- Myoclonus · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16566-F1 | alphafold | PREDICTED | 70.62 | — |
Amino-acid sequence (473 residues)
MLKVTVPSCS ASSCSSVTAS AAPGTASLVP DYWIDGSNRD ALSDFFEVES ELGRGATSIV YRCKQKGTQK PYALKVLKKT VDKKIVRTEI GVLLRLSHPN IIKLKEIFET PTEISLVLEL VTGGELFDRI VEKGYYSERD AADAVKQILE AVAYLHENGI VHRDLKPENL LYATPAPDAP LKIADFGLSK IVEHQVLMKT VCGTPGYCAP EILRGCAYGP EVDMWSVGII TYILLCGFEP FYDERGDQFM FRRILNCEYY FISPWWDEVS LNAKDLVRKL IVLDPKKRLT TFQALQHPWV TGKAANFVHM DTAQKKLQEF NARRKLKAAV KAVVASSRLG SASSSHGSIQ ESHKASRDPS PIQDGNEDMK AIPEGEKIQG DGAQAAVKGA QAELMKVQAL EKVKGADINA EEAPKMVPKA VEDGIKVADL ELEEGLAEEK LKTVEEAAAP REGQGSSAVG FEVPQQDVIL PEY
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