Cocaine- and amphetamine-regulated transcript…

About Cocaine- and amphetamine-regulated transcript protein

Cocaine- and amphetamine-regulated transcript protein (CARTPT) is a protein from Homo sapiens identified by UniProt accession Q16568, 116 residues long. MolForge cross-references it against 0 known binders and 195 disease associations.

Target properties

Protein name	Cocaine- and amphetamine-regulated transcript protein
UniProt accession	Q16568
Gene	CARTPT
Organism	Homo sapiens
Length	116 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (195)

Diseases linked to this target (Open Targets).

arterial stiffness measurement · score 0.24
pulse pressure measurement · score 0.22
obesity · score 0.13
MODY · score 0.09
type 2 diabetes mellitus · score 0.07
hyperinsulinism due to INSR deficiency · score 0.06
hyperinsulinemic hypoglycemia, familial, 2 · score 0.06
hyperinsulinemic hypoglycemia, familial, 1 · score 0.06
neoplasm · score 0.06
hyperinsulinism due to glucokinase deficiency · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16568-F1	alphafold	PREDICTED	74.32	—

Amino-acid sequence (116 residues)

MESSRVRLLP LLGAALLLML PLLGTRAQED AELQPRALDI YSAVDDASHE KELIEALQEV LKKLKSKRVP IYEKKYGQVP MCDAGEQCAV RKGARIGKLC DCPRGTSCNS FLLKCL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Cocaine- and amphetamine-regulated transcript protein (CARTPT)