Atypical chemokine receptor 1 (ACKR1)

About Atypical chemokine receptor 1

Atypical chemokine receptor 1 (ACKR1) is a protein from Homo sapiens identified by UniProt accession Q16570, 336 residues long. MolForge cross-references it against 0 known binders and 270 disease associations.

Target properties

Protein name	Atypical chemokine receptor 1
UniProt accession	Q16570
Gene	ACKR1
Organism	Homo sapiens
Length	336 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (270)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.45
monocyte count · score 0.45
leukocyte count · score 0.45
myeloid white cell count · score 0.43
basophil count · score 0.43
basophil percentage of leukocytes · score 0.42
CCL2 measurement · score 0.42
blood protein measurement · score 0.42
lymphocyte percentage of leukocytes · score 0.42
neutrophil percentage of leukocytes · score 0.41

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16570-F1	alphafold	PREDICTED	78.33	—

Amino-acid sequence (336 residues)

MGNCLHRAEL SPSTENSSQL DFEDVWNSSY GVNDSFPDGD YGANLEAAAP CHSCNLLDDS ALPFFILTSV LGILASSTVL FMLFRPLFRW QLCPGWPVLA QLAVGSALFS IVVPVLAPGL GSTRSSALCS LGYCVWYGSA FAQALLLGCH ASLGHRLGAG QVPGLTLGLT VGIWGVAALL TLPVTLASGA SGGLCTLIYS TELKALQATH TVACLAIFVL LPLGLFGAKG LKKALGMGPG PWMNILWAWF IFWWPHGVVL GLDFLVRSKL LLLSTCLAQQ ALDLLLNLAE ALAILHCVAT PLLLALFCHQ ATRTLLPSLP LPEGWSSHLD TLGSKS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards