About Vesicular acetylcholine transporter
Vesicular acetylcholine transporter (SLC18A3) is a protein
from Homo sapiens identified by UniProt accession
Q16572, 532 residues long.
MolForge cross-references it against 0 known binders and
186 disease associations.
Target properties
| Protein name | Vesicular acetylcholine transporter |
|---|
| UniProt accession | Q16572 |
|---|
| Gene | SLC18A3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 532 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (186)
Diseases linked to this target (Open Targets).
- Congenital myasthenic syndromes · score 0.62
- Presynaptic congenital myasthenic syndromes · score 0.50
- neurodegenerative disease · score 0.37
- fetal akinesia deformation sequence · score 0.37
- glioblastoma multiforme · score 0.23
- genetic disorder · score 0.19
- arthrogryposis · score 0.19
- lung adenocarcinoma · score 0.18
- cutaneous melanoma · score 0.13
- squamous cell lung carcinoma · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16572-F1 | alphafold | PREDICTED | 76.20 | — |
Amino-acid sequence (532 residues)
MESAEPAGQA RAAATKLSEA VGAALQEPRR QRRLVLVIVC VALLLDNMLY MVIVPIVPDY IAHMRGGGEG PTRTPEVWEP TLPLPTPANA SAYTANTSAS PTAAWPAGSA LRPRYPTESE DVKIGVLFAS KAILQLLVNP LSGPFIDRMS YDVPLLIGLG VMFASTVLFA FAEDYATLFA ARSLQGLGSA FADTSGIAMI ADKYPEEPER SRALGVALAF ISFGSLVAPP FGGILYEFAG KRVPFLVLAA VSLFDALLLL AVAKPFSAAA RARANLPVGT PIHRLMLDPY IAVVAGALTT CNIPLAFLEP TIATWMKHTM AASEWEMGMA WLPAFVPHVL GVYLTVRLAA RYPHLQWLYG ALGLAVIGAS SCIVPACRSF APLVVSLCGL CFGIALVDTA LLPTLAFLVD VRHVSVYGSV YAIADISYSV AYALGPIVAG HIVHSLGFEQ LSLGMGLANL LYAPVLLLLR NVGLLTRSRS ERDVLLDEPP QGLYDAVRLR ERPVSGQDGE PRSPPGPFDA CEDDYNYYYT RS
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