About C3a anaphylatoxin chemotactic receptor
C3a anaphylatoxin chemotactic receptor (C3AR1) is a protein
from Homo sapiens identified by UniProt accession
Q16581, 482 residues long.
MolForge cross-references it against 0 known binders and
426 disease associations.
Target properties
| Protein name | C3a anaphylatoxin chemotactic receptor |
|---|
| UniProt accession | Q16581 |
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| Gene | C3AR1 |
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| Organism | Homo sapiens |
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| Length | 482 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (426)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.38
- neutrophil percentage of leukocytes · score 0.32
- atypical hemolytic-uremic syndrome · score 0.26
- monocyte percentage of leukocytes · score 0.25
- granulocyte percentage of myeloid white cells · score 0.25
- visual perception measurement · score 0.21
- breast adenocarcinoma · score 0.17
- head and neck squamous cell carcinoma · score 0.16
- inflammatory bowel disease · score 0.15
- myeloid white cell count · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16581-F1 | alphafold | PREDICTED | 68.82 | — |
Amino-acid sequence (482 residues)
MASFSAETNS TDLLSQPWNE PPVILSMVIL SLTFLLGLPG NGLVLWVAGL KMQRTVNTIW FLHLTLADLL CCLSLPFSLA HLALQGQWPY GRFLCKLIPS IIVLNMFASV FLLTAISLDR CLVVFKPIWC QNHRNVGMAC SICGCIWVVA FVMCIPVFVY REIFTTDNHN RCGYKFGLSS SLDYPDFYGD PLENRSLENI VQPPGEMNDR LDPSSFQTND HPWTVPTVFQ PQTFQRPSAD SLPRGSARLT SQNLYSNVFK PADVVSPKIP SGFPIEDHET SPLDNSDAFL STHLKLFPSA SSNSFYESEL PQGFQDYYNL GQFTDDDQVP TPLVAITITR LVVGFLLPSV IMIACYSFIV FRMQRGRFAK SQSKTFRVAV VVVAVFLVCW TPYHIFGVLS LLTDPETPLG KTLMSWDHVC IALASANSCF NPFLYALLGK DFRKKARQSI QGILEAAFSE ELTRSTHCPS NNVISERNST TV
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