Beta-sarcoglycan (SGCB)

About Beta-sarcoglycan

Beta-sarcoglycan (SGCB) is a protein from Homo sapiens identified by UniProt accession Q16585, 318 residues long. MolForge cross-references it against 0 known binders and 491 disease associations.

Target properties

Protein name	Beta-sarcoglycan
UniProt accession	Q16585
Gene	SGCB
Organism	Homo sapiens
Length	318 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (491)

Diseases linked to this target (Open Targets).

autosomal recessive limb-girdle muscular dystrophy type 2E · score 0.81
limb-girdle muscular dystrophy · score 0.67
autosomal recessive limb-girdle muscular dystrophy · score 0.65
qualitative or quantitative defects of beta-sarcoglycan · score 0.47
genetic disorder · score 0.46
Abnormality of the musculature · score 0.44
dilated cardiomyopathy · score 0.38
sialidosis · score 0.27
platelet count · score 0.25
neurodegenerative disease · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16585-F1	alphafold	PREDICTED	76.42	—

Amino-acid sequence (318 residues)

MAAAAAAAAE QQSSNGPVKK SMREKAVERR SVNKEHNSNF KAGYIPIDED RLHKTGLRGR KGNLAICVII LLFILAVINL IITLVIWAVI RIGPNGCDSM EFHESGLLRF KQVSDMGVIH PLYKSTVGGR RNENLVITGN NQPIVFQQGT TKLSVENNKT SITSDIGMQF FDPRTQNILF STDYETHEFH LPSGVKSLNV QKASTERITS NATSDLNIKV DGRAIVRGNE GVFIMGKTIE FHMGGNMELK AENSIILNGS VMVSTTRLPS SSSGDQLGSG DWVRYKLCMC ADGTLFKVQV TSQNMGCQIS DNPCGNTH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards