Alpha-sarcoglycan (SGCA)

About Alpha-sarcoglycan

Alpha-sarcoglycan (SGCA) is a protein from Homo sapiens identified by UniProt accession Q16586, 387 residues long. MolForge cross-references it against 0 known binders and 286 disease associations.

Target properties

Protein name	Alpha-sarcoglycan
UniProt accession	Q16586
Gene	SGCA
Organism	Homo sapiens
Length	387 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (286)

Diseases linked to this target (Open Targets).

autosomal recessive limb-girdle muscular dystrophy type 2D · score 0.84
limb-girdle muscular dystrophy · score 0.67
autosomal recessive limb-girdle muscular dystrophy · score 0.62
Abnormality of the musculature · score 0.51
sarcoglycanopathy · score 0.50
heel bone mineral density · score 0.36
genetic disorder · score 0.19
cortical surface area measurement · score 0.13
qualitative or quantitative defects of alpha-sarcoglycan · score 0.12
cup-to-disc ratio measurement · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16586-F1	alphafold	PREDICTED	80.02	—

Amino-acid sequence (387 residues)

MAETLFWTPL LVVLLAGLGD TEAQQTTLHP LVGRVFVHTL DHETFLSLPE HVAVPPAVHI TYHAHLQGHP DLPRWLRYTQ RSPHHPGFLY GSATPEDRGL QVIEVTAYNR DSFDTTRQRL VLEIGDPEGP LLPYQAEFLV RSHDAEEVLP STPASRFLSA LGGLWEPGEL QLLNVTSALD RGGRVPLPIE GRKEGVYIKV GSASPFSTCL KMVASPDSHA RCAQGQPPLL SCYDTLAPHF RVDWCNVTLV DKSVPEPADE VPTPGDGILE HDPFFCPPTE APDRDFLVDA LVTLLVPLLV ALLLTLLLAY VMCCRREGRL KRDLATSDIQ MVHHCTIHGN TEELRQMAAS REVPRPLSTL PMFNVHTGER LPPRVDSAQV PLILDQH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards