About Zinc finger protein 74
Zinc finger protein 74 (ZNF74) is a protein
from Homo sapiens identified by UniProt accession
Q16587, 644 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | Zinc finger protein 74 |
|---|
| UniProt accession | Q16587 |
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| Gene | ZNF74 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 644 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (16)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.20
- PHF-tau measurement · score 0.17
- balding measurement · score 0.10
- small intestine carcinoma · score 0.09
- type 2 diabetes mellitus · score 0.07
- complication · score 0.05
- appendicular lean mass · score 0.04
- FEV/FVC ratio · score 0.04
- forced expiratory volume · score 0.04
- brain measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16587-F1 | alphafold | PREDICTED | 65.31 | — |
Amino-acid sequence (644 residues)
MEIPAPEPEK TALSSQDPAL SLKENLEDIS GWGLPEARSK ESVSFKDVAV DFTQEEWGQL DSPQRALYRD VMLENYQNLL ALGPPLHKPD VISHLERGEE PWSMQREVPR GPCPEWELKA VPSQQQGICK EEPAQEPIME RPLGGAQAWG RQAGALQRSQ AAPWAPAPAM VWDVPVEEFP LRCPLFAQQR VPEGGPLLDT RKNVQATEGR TKAPARLCAG ENASTPSEPE KFPQVRRQRG AGAGEGEFVC GECGKAFRQS SSLTLHRRWH SREKAYKCDE CGKAFTWSTN LLEHRRIHTG EKPFFCGECG KAFSCHSSLN VHQRIHTGER PYKCSACEKA FSCSSLLSMH LRVHTGEKPY RCGECGKAFN QRTHLTRHHR IHTGEKPYQC GSCGKAFTCH SSLTVHEKIH SGDKPFKCSD CEKAFNSRSR LTLHQRTHTG EKPFKCADCG KGFSCHAYLL VHRRIHSGEK PFKCNECGKA FSSHAYLIVH RRIHTGEKPF DCSQCWKAFS CHSSLIVHQR IHTGEKPYKC SECGRAFSQN HCLIKHQKIH SGEKSFKCEK CGEMFNWSSH LTEHQRLHSE GKPLAIQFNK HLLSTYYVPG SLLGAGDAGL RDVDPIDALD VAKLLCVVPP RAGRNFSLGS KPRN
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