About Frataxin, mitochondrial
Frataxin, mitochondrial (FXN) is a protein
from Homo sapiens identified by UniProt accession
Q16595, 210 residues long.
MolForge cross-references it against 0 known binders and
204 disease associations.
Target properties
| Protein name | Frataxin, mitochondrial |
|---|
| UniProt accession | Q16595 |
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| Gene | FXN |
|---|
| Organism | Homo sapiens |
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| Length | 210 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (204)
Diseases linked to this target (Open Targets).
- Friedreich ataxia · score 0.81
- neurodegenerative disease · score 0.54
- genetic disorder · score 0.34
- Headache · score 0.29
- Agents acting on the renin-angiotensin system use measurement · score 0.15
- hypertrophic cardiomyopathy · score 0.12
- neoplasm · score 0.08
- FRAXF syndrome · score 0.05
- mean corpuscular volume · score 0.05
- refractive error · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16595-F1 | alphafold | PREDICTED | 75.51 | — |
Amino-acid sequence (210 residues)
MWTLGRRAVA GLLASPSPAQ AQTLTRVPRP AELAPLCGRR GLRTDIDATC TPRRASSNQR GLNQIWNVKK QSVYLMNLRK SGTLGHPGSL DETTYERLAE ETLDSLAEFF EDLADKPYTF EDYDVSFGSG VLTVKLGGDL GTYVINKQTP NKQIWLSSPS SGPKRYDWTG KNWVYSHDGV SLHELLAAEL TKALKTKLDL SSLAYSGKDA
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